Home > Seminars > Reilly Lecture: Advances in siRNA and Protein Delivery Through Smart Polymers

Reilly Lecture: Advances in siRNA and Protein Delivery Through Smart Polymers

Start:

3/31/2015 at 3:30PM

End:

3/31/2015 at 4:30PM

Location:

Eck Visitors Center Auditorium

Host:

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Edward Maginn

Edward Maginn

VIEW FULL PROFILE Email: ed@nd.edu
Phone: 574-631-5687
Website: http://www.nd.edu/~ed/
Office: 182A Fitzpatrick Hall

Affiliations

Department of Chemical and Biomolecular Engineering Dorini Family Professor of Energy Studies and Department Chair
College of Engineering Dorini Family Professor of Energy Studies and Chair of the Department of Chemical and Biomolecular Engineering
The research in our group focuses on developing a fundamental understanding of the link between the physical properties of materials and their chemical constitution. Much of our work is devoted to applications related to energy and the environment. The main tool we use is molecular simulation. In ...
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Engineering the molecular design of intelligent biomaterials by controlling structure, recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes.  Recent developments in siRNA and protein delivery have been directed towards the preparation of targeted formulations for protein delivery to specific sites, use of environmentally-responsive polymers to achieve pH- or temperature-triggered delivery, usually in modulated mode, and improvement of the behavior of their mucoadhesive behavior and cell recognition.  We address design and synthesis characteristics of novel crosslinked networks capable of protein release as well as artificial molecular structures capable of specific molecular recognition of biological molecules. Molecular imprinting and microimprinting techniques, which create stereo-specific three-dimensional binding cavities based on a biological compound of interest can lead to preparation of biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering. We have been successful in synthesizing novel glucose- and protein-binding molecules based on non-covalent directed interactions formed via molecular imprinting techniques within aqueous media. We have also developed structurally superior materials to serve as effective carriers for siRNA delivery to combat Crohn's disease and ulcerative colitis.

Seminar Speaker:

Nicholas A. Peppas

Nicholas A. Peppas

University of Texas at Austin

Nicholas A. Peppas is the Cockrell Family Regents Chaired Professor in the Departments of Chemical, Biomedical Engineering and Pharmacy, Chairman of the Department of Biomedical Engineering and Director of the Institute of Biomaterials, Drug Delivery and Regenerative Medicine of the University of Texas at Austin.  His work in biomaterials, polymer physics, drug delivery and bionanotechnology follows a multidisciplinary approach by blending modern molecular and cellular biology with engineering principles to design the next-generation of medical systems and devices for patient treatment. Over the past 40 years he has set the fundamentals and rational design of drug delivery systems  and developed models of drug and protein diffusion in controlled release devices and biological tissues. In 2012 he received the Founders Award of the National Academy of Engineering (NAE), the highest recognition of the Academy, for these contributions to the field. Peppas is a member of the NAE, Institute of Medicine of the National Academies, National Academy of Inventors, the National Academy of France, the Royal Academy of Spain, the Academy of Athens and the Academy of Texas.  He has been recognized with awards from AIChE (Founders Award, William Walker Award, Institute Lecture, Jay Bailey Award, Bioengineering Award, Materials Award), the Biomedical Engineering Society (Distinguished Scientist Award), the American Institute of Medical and Biological Engineering (Galletti Award), the Society for Biomaterials (Founders, Clemson and Hall Awards), the Controlled Release Society (Founders, Heller and Eurand Awards) and other societies. In 2008, AIChE named him one of the One Hundred Chemical Engineers of the Modern Era. He is President of the International Union of Societies of Biomaterials Science and Engineering, Chair of the Engineering Section of the American Association for the Advancement of Science, and Past-Chair of the Council of BME Chairs. Previously, he served as President of SFB and the Controlled Release Society.  He is a fellow of AAAS, AIChE, APS, ACS, MRS, SFB, BMES, AIMBE, CRS, AAPS, and ASEE. He  has supervised the research of 100 PhDs and about 180 postdocs and graduate students. Peppas holds a Dipl. Eng. from the NTU of  Athens (1971), a Sc.D. from MIT (1973), and honorary doctorates from the Universities of Ghent, Parma, Athens, Ljubljana and Sichuan.

Seminar Sponsors:

Reilly Lectureship

Initiated in 1958, the distinguished Reilly Lectureship is the oldest continuing endowed lectureship in chemical and biomolecular engineering in the United States. The lecture series is supported by the Peter C. Reilly Fund, which was established in 1945 in honor of the late Peter C. Reilly, a former University Trustee and recipient of an honorary LLD degree. Peter Reilly started the chemical company in Indianapolis that came to be called Reilly Industries and was a big supporter of Notre Dame.

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Sponsors

Reilly Lectureship

Initiated in 1958, the distinguished Reilly Lectureship is the oldest continuing endowed lectureship in chemical and biomolecular engineering in the United States. The lecture series is supported by the Peter C. Reilly Fund, which was established in 1945 in honor of the late Peter C. Reilly, a former University Trustee and recipient of an honorary LLD degree. Peter Reilly started the chemical company in Indianapolis that came to be called Reilly Industries and was a big supporter of Notre Dame.