Home > Christopher Alabi: Design and Activity of Sequence-Defined Macromolecules

Christopher Alabi: Design and Activity of Sequence-Defined Macromolecules


2/12/2019 at 12:30PM


2/12/2019 at 1:30PM


102 DeBartolo Hall


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Matthew Webber

Matthew Webber

VIEW FULL PROFILE Email: mwebber@nd.edu
Phone: 574-631-4246
Website: http://www.webberlab.com/
Office: 205B McCourtney Hall


Research interests: • Supramolecular Biomaterials: The use of non-covalent molecular recognition motifs to engineer highly tunable, dynamic, modular, and bioactive materials for biomedical and biological applications (see Webber et al. Nature Materials 2016) • “Smart” Drug Delivery and ...
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Control over primary sequence is critical to the development of new functional materials such as catalysts, affinity ligands, therapeutics, sequence responsive scaffolds, programmable materials and much more. Motivated by these opportunities and the need for sequence-control and structural diversity in polymer research, I will present two versatile strategies for the assembly of new sequence-defined macromolecules. In addition to sequence-control, my lab is currently working to establish sensitive structural characterization methods to determine their conformational dynamics and to formulate sequence-structure relationships for material and biological applications. In one scenario, we focus on the design of antibacterial agents that leverage the advantages of novel oligothioetheramide (oligoTEA) macromolecules such as stability to serum proteases and precise control of backbone and pendant group sequence. In another area, we overcome the scalability issue that plagues the iterative assembly of sequence-defined macromolecules by creating sequence-defined polyurethane oligomers on a gram-scale via sequential and support-free reductive amination and acylation reactions. Data highlighting the effect of sequence on material properties will be presented. This body of work should provide the foundation for future studies exploring the tunability of bulk material properties via sequence control.

Seminar Speaker:

Christopher Alabi

Christopher Alabi

Cornell Univeristy

Professor Alabi began his research career as an undergraduate student under the direction of Professor David Schuster at NYU. Upon receiving his B.S. in Chemistry from NYU and B.E. in Chemical Engineering from Stevens Institute of Technology, he went on to pursue a graduate degree in Materials Chemistry at California Institute of Technology with Professor Mark Davis. He then moved to MIT in 2009 and served as NIH Postdoctoral Fellow with Professor Langer and Anderson. Chris joined the Cornell faculty in 2013 as an Assistant Professor in the School of Chemical and Biomolecular Engineering. He has won several awards during his short tenure at Cornell including the PhRMA Foundation Research Starter Award, NSF CAREER Award, the 2016 Cornell Engineering Research Excellence Award, the 2017 Tau Beta Pi Professor of the Year Award and the 2018 PMSE Young Investigator Award.